NR-11c

CAT: 0804-HY-159798-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-159798-01Size:5 mg
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Description
NR-11c is a selective and potent p38α PROTAC degrader. NR-11c effectively degrades p38α in a variety of tumor cells. When administered intraperitoneally or intravenously to mice, NR-11c primarily acts in the liver. NR-11c can be used in cancer research. (Pink: p38α inhibitor 5 (HY-159799) ; Black: linker (HY-159800) ; Blue: VHL E3 ligase ligand (HY-112078) ) [1].
UNSPSC
12352005
Target
P38 MAPK; PROTACs
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nr-11c.html
Purity
99.75
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C([C@H]1N(C([C@@H](NC(CCCCCNC(CCCN2N=NC(CCCNC(C3=CC=C(C)C(N4C(C)=CC(OCC5=CC=C(F)C=C5F)=C(Br)C4=O)=C3)=O)=C2)=O)=O)C(C)(C)C)=O)C[C@@H](O)C1)N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C
Molecular Formula
C59H71BrF2N10O8S
Molecular Weight
1198.22
References & Citations
[1]Cubillos-Rojas M, et al. Synthesis and Biological Activity of a VHL-Based PROTAC Specific for p38α. Cancers (Basel) . 2023 Jan 18;15 (3) :611.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P38α

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