NR-11c

• Description:

  NR-11c is a selective and potent p38α PROTAC degrader. NR-11c effectively degrades p38α in a variety of tumor cells. When administered intraperitoneally or intravenously to mice, NR-11c primarily acts in the liver. NR-11c can be used in cancer research. (Pink: p38α inhibitor 5 (HY-159799) ; Black: linker (HY-159800) ; Blue: VHL E3 ligase ligand (HY-112078) ) [1].

• UNSPSC:

  12352005

• Target:

  P38 MAPK; PROTACs

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway; PROTAC

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nr-11c.html

• Purity:

  99.75

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C([C@H]1N(C([C@@H](NC(CCCCCNC(CCCN2N=NC(CCCNC(C3=CC=C(C)C(N4C(C)=CC(OCC5=CC=C(F)C=C5F)=C(Br)C4=O)=C3)=O)=C2)=O)=O)C(C)(C)C)=O)C[C@@H](O)C1)N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C

• Molecular Formula:

  C59H71BrF2N10O8S

• Molecular Weight:

  1198.22

• References & Citations:

  [1]Cubillos-Rojas M, et al. Synthesis and Biological Activity of a VHL-Based PROTAC Specific for p38α. Cancers (Basel) . 2023 Jan 18;15 (3) :611.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  P38α