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Anti-Ms CD41 PE

CAT: 0270-1P-763-C100Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0270-1P-763-C100Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, alpha and 23 kDa b, beta) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.
Certification
RUO
Reactivity
Mouse
Immunogen
Murine platelets
Target Antigen
CD41
Clone
MWReg30
Applications
FC (QC tested)
Concentration
0.5 mg/mL
Format
PE
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Ramsey H, Zhang Q, Brown DE, Steensma DP, Lin CP, Wu MX: Stress-induced hematopoietic failure in the absence of immediate early response gene X-1. Haematologica. 2013 Sep 20. [Epub ahead of print], URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=ramsey+h+steensma+dp , *Sullivan BP, Wang R, Tawfik O, Luyendyk JP: Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies. Toxicol Sci. 2010 May;115 (1) :286-94., URL: http://www.ncbi.nlm.nih.gov/pubmed/20133375 , *Boisset JC, Clapes T, Van Der Linden R, Dzierzak E, Robin C: Integrin α IIb (CD41) plays a role in the maintenance of hematopoietic stem cell activity in the mouse embryonic aorta. Biol Open. 2013 Apr 11;2 (5) :525-32., URL: http://www.ncbi.nlm.nih.gov/pubmed/23789102 , *Brancaleone V, Gobbetti T, Cenac N, le Faouder P, Colom B, Flower RJ, Vergnolle N, Nourshargh S, Perretti M: A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation. Blood. 2013 Jul 25;122 (4) :608-17., URL: https://pubmed.ncbi.nlm.nih.gov/23733341/
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The rat monoclonal antibody MWReg30 recognizes an extracellular epitope of CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa) . CD41 is mainly expressed on platelets and megakaryocytes.
Applications Notes
Flow cytometry: Recommended dilution: 1-5 μg/ml.
Isotype
Rat IgG1 kappa

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