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Anti-Ms CD49e PE

CAT: 0270-1P-743-C100Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0270-1P-743-C100Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD49e, the alpha 5 integrin, noncovalently associates with the beta 1integrin (CD29) to form VLA-5 integrin complex. CD49e itself is composed of two disulfide-linked chains of 135 kDa and 25 kDa. VLA-5 binds to RGD sequence of fibronectin, and to neural adhesion molecule L1. It is important in maintaining the integrity of endothelial monolayers, in monocyte migration into the extracellular tissues, and it also provides a co-stimulatory signal to T cells and enhances receptor and complement receptor-mediated phagocytosis.
Certification
RUO
Reactivity
Mouse
Immunogen
C57BL/6 x A/J) F1 murine mast cell line
Target Antigen
CD49e
Clone
5H10-27 (MFR5)
Applications
FC (QC tested)
Concentration
0.5 mg/mL
Format
PE
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*van der Loo JC, Xiao X, McMillin D, Hashino K, Kato I, Williams DA: VLA-5 is expressed by mouse and human long-term repopulating hematopoietic cells and mediates adhesion to extracellular matrix protein fibronectin. J Clin Invest. 1998 Sep 1;102 (5) :1051-61., URL: https://pubmed.ncbi.nlm.nih.gov/9727075/, *Sampaio AL, Zahn G, Leoni G, Vossmeyer D, Christner C, Marshall JF, Perretti M: Inflammation-dependent alpha 5 beta 1 (very late antigen-5) expression on leukocytes reveals a functional role for this integrin in acute peritonitis. J Leukoc Biol. 2010 May;87 (5) :877-84., URL: https://pubmed.ncbi.nlm.nih.gov/20097849/, *Plett PA, Frankovitz SM, Orschell CM: Distribution of marrow repopulating cells between bone marrow and spleen early after transplantation. Blood. 2003 Sep 15;102 (6) :2285-91., URL: http://www.ncbi.nlm.nih.gov/pubmed/12775569
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The rat monoclonal antibody 5H10-27 (MFR5) recognizes an extracellular epitope of murine CD49e, a 135 kDa protein serving as VLA-5 alpha chain, expressed on thymocytes, activated T cells, splenic B cells, and mast cells.
Applications Notes
Flow cytometry: Recommended dilution: 1-4 μg/ml.
Isotype
Rat IgG2a kappa

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