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Anti-Ms CD197 PE

CAT: 0270-1P-735-C100Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0270-1P-735-C100Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD197 / CCR7 (chemokine receptor 7) is a seven membrane-spanning protein serving as a receptor for chemokines CCL19 and CCL21. It is expressed on most naive T cells, some hematopoietic stem cells, mature dendritic cells, NK cells and some memory T cells and B cells subsets. CD197 plays important roles in development of thymocytes, and regulating the recirculation and homing of lymphocytes and dendritic cells to secondary lymphoid organs.
Certification
RUO
Reactivity
Mouse
Immunogen
Murine CD197-transfected RBL-2H3 cells
Target Antigen
CD197
Clone
4B12
Applications
FC (QC tested)
Concentration
0.5 mg/mL
Format
PE
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Singh V, Gowthaman U, Jain S, Parihar P, Banskar S, Gupta P, Gupta UD, Agrewala JN: Coadministration of interleukins 7 and 15 with bacille Calmette-Guérin mounts enduring T cell memory response against Mycobacterium tuberculosis. J Infect Dis. 2010 Aug 15;202 (3) :480-9, URL: http://www.ncbi.nlm.nih.gov/pubmed/20569158, *Adachi K, Osada Y, Nakamura R, Tamada K, Hamano S: Unique T cells with unconventional cytokine profiles induced in the livers of mice during schistosoma mansoni infection. PLoS One. 2013 Dec 16;8 (12) :e82698., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=adachi+k+osada+y , *Huggins A, Paschalidis N, Flower RJ, Perretti M, D'Acquisto F: Annexin-1-deficient dendritic cells acquire a mature phenotype during differentiation. FASEB J. 2009 Apr;23 (4) :985-96, URL: http://www.ncbi.nlm.nih.gov/pubmed/19029200 , *Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA: NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature. 2012 Apr 25;484 (7395) :510-3, URL: https://pubmed.ncbi.nlm.nih.gov/22538615/
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The rat monoclonal antibody 4B12 recognizes an extracellular epitope of murine CD197 / CCR7 (chemokine receptor 7), a 43 kDa G-protein-coupled receptor for chemokines CCL19 and CCL21.
Applications Notes
Flow cytometry: Recommended dilution: 1-5 μg/ml.
Isotype
Rat IgG2a kappa

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