PF-998425

• Description:

  PF-998425 is a potent, selective nonsteroidal androgen receptor (AR) antagonist with an IC50 of 37 nM and 43 nM in AR binding and cellular assays, respectively. PF-998425 has low activity on common receptors and enzymes, such as progesterone receptor. PF-998425 can be used for sebum control and androgenetic alopecia research[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H319

• Target:

  Androgen Receptor

• Type:

  Reference compound

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/pf-998425.html

• Purity:

  98.31

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O[C@H]1[C@H] (CCCC1) C2=CC (C (F) (F) F) =C (C=C2) C#N

• Molecular Formula:

  C14H14F3NO

• Molecular Weight:

  269.26

• Precautions:

  H302, H319

• References & Citations:

  [1]Jie Jack Li, et al. Rational design and synthesis of 4- ((1R,2R) -2-hydroxycyclohexyl) -2 (trifluoromethyl) benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. J Med Chem. 2008 Nov 13;51 (21) :7010-4.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1076225-27-8