PF-998425

• Description :

  PF-998425 is a potent, selective nonsteroidal androgen receptor (AR) antagonist with an IC50 of 37 nM and 43 nM in AR binding and cellular assays, respectively. PF-998425 has low activity on common receptors and enzymes, such as progesterone receptor. PF-998425 can be used for sebum control and androgenetic alopecia research[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H319

• Target :

  Androgen Receptor

• Type :

  Reference compound

• Related Pathways :

  Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/pf-998425.html

• Purity :

  98.31

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O[C@H]1[C@H](CCCC1)C2=CC(C(F)(F)F)=C(C=C2)C#N

• Molecular Formula :

  C14H14F3NO

• Molecular Weight :

  269.26

• Precautions :

  H302, H319

• References & Citations :

  [1]Jie Jack Li, et al. Rational design and synthesis of 4- ((1R,2R) -2-hydroxycyclohexyl) -2 (trifluoromethyl) benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. J Med Chem. 2008 Nov 13;51 (21) :7010-4.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1076225-27-8]