SIRT6-IN-2

CAT: 0804-HY-103721-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-103721-01Size:5 mg

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Description

SIRT6-IN-2 (Compound 5) is a selective and competitive SIRT6 inhibitor (IC50: 34 μM) . SIRT6-IN-2 increases acetylation of H3K9 and increases glucose uptake in cultured cells. SIRT6-IN-2 also reduces T cell proliferation. SIRT6-IN-2 has immunosuppressive and chemosensitizing effects[1].

CAS Number

891002-11-2

UNSPSC

12352005

Hazard Statement

H315

Target

Sirtuin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sirt6-in-2.html

Concentration

10mM

Purity

99.85

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(NC(C2=CC=CO2)=O)C=C1)NC3=CC(C(O)=O)=C(O)C=C3

Molecular Formula

C19H14N2O6

Molecular Weight

366.32

Precautions

P264-P280-P302+P352-P362

References & Citations

[1]Damonte P, et al. SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects. Bioorg Med Chem. 2017 Oct 15;25 (20) :5849-5858.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

SIRT1; SIRT2; SIRT6

Chemical Information

5-[4-(Furan-2-amido)benzamido]-2-hydroxybenzoic acid

CAS Number	891002-11-2
PubChem CID	9324490
IUPAC Name	5-[[4-(furan-2-carbonylamino)benzoyl]amino]-2-hydroxybenzoic acid
Molecular Formula	C19H14N2O6
Molecular Weight	366.3
XLogP	2.7
Topological Polar Surface Area	129
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Heavy Atom Count	27
Formal Charge	0
Complexity	560

SMILES

C1=COC(=C1)C(=O)NC2=CC=C(C=C2)C(=O)NC3=CC(=C(C=C3)O)C(=O)O

InChI

InChI=1S/C19H14N2O6/c22-15-8-7-13(10-14(15)19(25)26)21-17(23)11-3-5-12(6-4-11)20-18(24)16-2-1-9-27-16/h1-10,22H,(H,20,24)(H,21,23)(H,25,26)

InChIKey

WCJCTRHTVZUWSD-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 891002-11-2

CID: 9324490

Formula: C19H14N2O6

MW: 366.3

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	366.3
XLogP3	2.7
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	366.08518617
Monoisotopic Mass	366.08518617
Topological Polar Surface Area	129 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	560
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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HY-P703626-01	SIRT6, Human (His)
HY-P702952-01	SIRT6, Human (GST)
HY-148712-01	SIRT6 activator 12q
HY-P85522	SIRT6 Antibody (YA5214, Mouse)
HY-P87707	SIRT6 Antibody (YA7392, Rabbit)
HY-P80322-01	SIRT6 Antibody (YA078, Rabbit)

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394411-01	SIRT6 discontinued
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MBS515687-01	SIRT6, Active
OM306007-01	SIRT6 Human

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Chemical Information

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