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SIRT6-IN-4

CAT: 0804-HY-170402Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170402Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SIRT6-IN-4 (Compound 10d) is a selective inhibitor for SIRT6 with an IC50 of 5.68 μM. SIRT6-IN-4 inhibits the proliferation of MCF-7 with an IC50 of 8.30 μM. SIRT6-IN-4 arrests the cell cycle at G2/M phase, inhibits thecell migration and invasion of MCF-7, and induces apoptosis. SIRT6-IN-4 exhibits antitumor efficacy in mouse models[1].
CAS Number
3075160-74-3
UNSPSC
12352005
Target
Apoptosis; Sirtuin
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C1=CC2=C(N(C3=C2C=C(C=C3)Cl)CC4=CC=C(C=C4)C#N)C=N1)NCC5=CC=CC=N5
Molecular Formula
C26H18ClN5O
Molecular Weight
451.91
References & Citations
[1]Liang C, et al., Structure-Guided Discovery of Subtype Selective SIRT6 Inhibitors with a β-Carboline Skeleton for the Treatment of Breast Cancer. J Med Chem. 2024 Dec 26;67 (24) :21975-22001.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT1; SIRT2; SIRT3; SIRT6

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