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SIRT6-IN-6

CAT: 0804-HY-16605-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16605-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SIRT6-IN-6 (compound 6d) is a potent and selective SIRT6 inhibitor with an IC50 of 4.93 μM and a Ki of ~10 μM. SIRT6-IN-6 shows selectivity against other members of the HDAC family (SIRT1-3 and HDAC1-11) . SIRT6-IN-6 significantly increases the level of glucose transporter GLUT-1, thereby reducing blood glucose in a mouse model of type 2 diabetes. SIRT6-IN-6 can be used for type 2 diabetes research[1].
CAS Number
23491-48-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GLUT; Sirtuin
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Membrane Transporter/Ion Channel
Field of Research
Metabolic Disease
Purity
99.63
Smiles
O=N(=O)C1=CC=C(C=C1N)N2CCN(C)CC2
Molecular Formula
C11H16N4O2
Molecular Weight
236.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Sun W, et al. Discovery of 5- (4-methylpiperazin-1-yl) -2-nitroaniline derivatives as a new class of SIRT6 inhibitors. Bioorg Med Chem Lett. 2020 Aug 15;30 (16) :127215.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Isoform
SIRT1; SIRT2; SIRT3; SIRT6

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