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SIRT6-IN-4

CAT: 0931-T204538-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T204538-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Sirtuin, Apoptosis
Related Pathways
Chromatin/Epigenetic, DNA Damage/DNA Repair, Apoptosis
Bioactivity
SIRT6-IN-4 (Compound 10d) is a selective inhibitor of SIRT6 with an IC50 of 5.68 μM. It inhibits the proliferation of MCF-7 cells, with an IC50 of 8.30 μM, and causes cell cycle arrest at the G2/M phase. Additionally, SIRT6-IN-4 impedes cell migration and invasion of MCF-7 and induces apoptosis. In mouse models, this compound exhibits antitumor activity.
Smiles
C1=CC=NC(=C1)CNC(=O)C2=NC=C3C(=C2)C4=C(N3CC5=CC=C(C=C5)C#N)C=CC(=C4)Cl
Molecular Formula
C26H18ClN5O
Molecular Weight
451.907
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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