Ac-DEVD-CMK

• Description:

  Ac-DEVD-CMK (Caspase-3 Inhibitor III) is a selective and irreversible caspase-3 inhibitor. Ac-DEVD-CMK significantly inhibits apoptosis induced by high levels of glucose or Ingenol 3,20-dibenzoate? (HY-137295) . Ac-DEVD-CMK can be used in a variety of experimental approaches to inhibit apoptosis[1][2][3].

• Product Name Alternative:

  Caspase-3 Inhibitor III

• UNSPSC:

  12352209

• Target:

  Apoptosis; Caspase

• Type:

  Peptides

• Related Pathways:

  Apoptosis

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/ac-devd-cmk.html

• Purity:

  98.60

• Solubility:

  10 mM in DMSO

• Smiles:

  ClCC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC(O)=O)=O)=O)=O)=O

• Molecular Formula:

  C21H31ClN4O11

• Molecular Weight:

  550.94

• References & Citations:

  [1]Lu Cai, et al. Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway. Diabetes. 2002 Jun;51 (6) :1938-48.|[2]M M Mocanu, et al. Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury. Br J Pharmacol. 2000 May;130 (2) :197-200.|[3]M Blanco-Molina, et al. Ingenol esters induce apoptosis in Jurkat cells through an AP-1 and NF-kappaB independent pathway. Chem Biol. 2001 Aug;8 (8) :767-78.|[4]Eon Jeong Nam, et al. Syndecan-1 limits the progression of liver injury and promotes liver repair in acetaminophen-induced liver injury in mice. Hepatology. 2017 Nov;66 (5) :1601-1615.|[5]Hung KC, et al. Citrate-Induced p85α⁻PTEN Complex Formation Causes G2/M Phase Arrest in Human Pharyngeal Squamous Carcinoma Cell Lines. Int J Mol Sci. 2019 Apr 29;20 (9) :2105.|[6]Nam EJ, et al. Syndecan-1 limits the progression of liver injury and promotes liver repair in acetaminophen-induced liver injury in mice. Hepatology. 2017 Nov;66 (5) :1601-1615.|[7]Eon Jeong Nam, et al. Syndecan-1 limits the progression of liver injury and promotes liver repair in acetaminophen-induced liver injury in mice. Hepatology. 2017 Nov;66 (5) :1601-1615.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  Caspase 3

• Citation 01:

  Exp Neurol. 2024 Mar:373:114678.|J Agric Food Chem. 2025 Aug 27;73 (34) :21296-21308.|PLoS Pathog. 2024 Jul 22;20 (7) :e1012408.

• CAS Number:

  [285570-60-7]