Ac-DEVD-pNA

• Description :

  Ac-DEVD-pNA is a ligand for caspase-3/-7 and related cysteine proteases[1][2].

• UNSPSC :

  12352209

• Hazard Statement :

  H302, H315, H319

• Target :

  Caspase

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/Ac-DEVD-pNA.html

• Purity :

  98.96

• Solubility :

  DMSO : 32.26 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

• Smiles :

  O=C(N[C@@H](C(C)C)C(N[C@H](C(O)=O)CC(NC1=CC=C([N+]([O-])=O)C=C1)=O)=O)[C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC(O)=O)=O

• Molecular Formula :

  C26H34N6O13

• Molecular Weight :

  638.58

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]Talanian RV, et al. Substrate specificities of caspase family proteases. J Biol Chem. 1997 Apr 11;272 (15) :9677-82.|[2]Peterson QP, et al. Preparation of the caspase-3/7 substrate Ac-DEVD-pNA by solution-phase peptide synthesis. Nat Protoc. 2010 Feb;5 (2) :294-302.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Caspase 3; Caspase 7

• CAS Number :

  [189950-66-1]