Ac-DMLD-CMK

• Description :

  Ac-DMLD-CMK is a polypeptide targeting the mouse caspase 3-Gsdme signaling pathway. Ac-DMLD-CMK can specifically inhibit the activation of caspase 3 and Gsdme. Ac-DMLD-CMK blocks the cleavage of Gsdme by caspase 3, inhibits the occurrence of pyroptosis, thereby reducing renal tubular epithelial cell injury and the secretion of inflammatory cytokines. Ac-DMLD-CMK reduces the levels of serum creatinine and blood urea nitrogen in mice induced by Cisplatin (HY-17394) and alleviates the deterioration of kidney function. Ac-DMLD-CMK is promising for research of chemotherapy drug-induced nephrotoxicity[1].

• UNSPSC :

  12352209

• Target :

  Caspase; Pyroptosis

• Related Pathways :

  Apoptosis; Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Smiles :

  ClCC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CCSC)NC([C@@H](NC(C)=O)CC(O)=O)=O)=O)=O)=O

• Molecular Formula :

  C22H35ClN4O9S

• Molecular Weight :

  567.05

• References & Citations :

  [1]Shen X, et al. Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity. Cell Death Dis. 2021 Feb 15;12 (2) :186.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• Isoform :

  Caspase 3

• CAS Number :

  [2588354-33-8]