Ac-DMLD-CMK

CAT: 0804-HY-P10939Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P10939Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Ac-DMLD-CMK is a polypeptide targeting the mouse caspase 3-Gsdme signaling pathway. Ac-DMLD-CMK can specifically inhibit the activation of caspase 3 and Gsdme. Ac-DMLD-CMK blocks the cleavage of Gsdme by caspase 3, inhibits the occurrence of pyroptosis, thereby reducing renal tubular epithelial cell injury and the secretion of inflammatory cytokines. Ac-DMLD-CMK reduces the levels of serum creatinine and blood urea nitrogen in mice induced by Cisplatin (HY-17394) and alleviates the deterioration of kidney function. Ac-DMLD-CMK is promising for research of chemotherapy drug-induced nephrotoxicity[1].
CAS Number
[2588354-33-8]
UNSPSC
12352209
Target
Caspase; Pyroptosis
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
ClCC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CCSC)NC([C@@H](NC(C)=O)CC(O)=O)=O)=O)=O)=O
Molecular Formula
C22H35ClN4O9S
Molecular Weight
567.05
References & Citations
[1]Shen X, et al. Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity. Cell Death Dis. 2021 Feb 15;12 (2) :186.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
Caspase 3

Related Products

CatalogName
HY-P0034-01Ac-DEVD-CMK
HY-16990-01Ac-YVAD-cmk
HY-204478Ac-KVPL-CMK
HY-P3434Ac-FEID-CMK
HY-P10243Ac-VAD-CMK
HY-111675-01Ac-FLTD-CMK
HY-204478A-01Ac-KVPL-CMK (TFA)
HY-P3434A-01Ac-FEID-CMK (TFA)
HY-P0034A-01Ac-DEVD-CMK (TFA)
HY-52101-01CMK

Alternative Products

CatalogName
MF-0064052-01Ac-DMLD-CMK
MBS5818165Ac-FEID-CMK
ALX-260-028-M005Ac-YVAD-CMK
7242/1Ac-FLTD-CMK
C5528-1Ac-DEVD-CMK
MF-0064125-01Ac-VAD-CMK
MBS566147-01Ac-YVAD-CMK [Caspase-1 Inhibitor (CMK)]
BUP00531-01Ac-FEID-CMK TFA

Popular Products