MAPK-IN-1

MAPK-IN-1

• CAS Number: 2470587-69-8
• UNSPSC Description: MAPK-IN-1 (Compound 2) is a MAPK signaling pathway inhibitor. MAPK-IN-1 exhibits AChE inhibitory activity with an IC50 of 23.84 μM. MAPK-IN-1 shows anti-neuroinflammatory and neuroprotective activity and can be used for Alzheimer's disease research[1].
• Target Antigen: Cholinesterase (ChE); ERK; JNK; p38 MAPK; Toll-like Receptor (TLR)
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;MAPK/ERK Pathway;Neuronal Signaling;Stem Cell/Wnt
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/mapk-in-1.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C1CCC(C2=C(C3=C(C(C2=O)=O)[C@@H](C)CO3)C=C4)=C4C1(C)C
• Molecular Weight: 310.34
• References & Citations: [1]Wu JS, et al. The oxygenated products of cryptotanshinone by biotransformation with Cunninghamella elegans exerting anti-neuroinflammatory effects by inhibiting TLR 4-mediated MAPK signaling pathway. Bioorg Chem. 2020 Nov;104:104246.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported