ERK2/p38α MAPK-IN-1

ERK2/p38α MAPK-IN-1

• CAS Number: 1016427-72-7
• UNSPSC Description: ERK2/p38α MAPK-IN-1 (Compound 1, In silico Hit-2) is a potent and selective ERK2 and p38α MAPK inhibitor, with an IC50 of 82 μM for ERK2. ERK2/p38α MAPK-IN-1 binds to the allosteric site of ERK2 and p38α MAPK in distinct manners. ERK2/p38α MAPK-IN-1 can be used for the research of type 2 diabetes[1].
• Target Antigen: ERK; p38 MAPK
• Type: Reference compound
• Related Pathways: MAPK/ERK Pathway;Stem Cell/Wnt
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/erk2-p38α-mapk-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: COC1=C(OC)C=C(N=C(NC(C2=CSC(COC3=CC=C(F)C=C3)=N2)=O)S4)C4=C1
• Molecular Weight: 445.49
• References & Citations: [1]Hasegawa S, et al. Distinct binding modes of a benzothiazole derivative confer structural bases for increasing ERK2 or p38α MAPK selectivity. Biochem Biophys Res Commun. 2024 Apr 16;704:149707.|[2]Kinoshita T, et al. Identification of allosteric ERK2 inhibitors through in silico biased screening and competitive binding assay. Bioorg Med Chem Lett. 2016 Feb 1;26(3):955-958.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported