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P38-α MAPK-IN-1

CAT: 0804-HY-18874-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18874-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
P38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay[1].
CAS Number
443913-15-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Autophagy; p38 MAPK
Type
Reference compound
Related Pathways
Autophagy; MAPK/ERK Pathway
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/p38-_alpha__MAPK-IN-1.html
Concentration
10mM
Purity
99.71
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC=C(N2C(NC(NC3=CC=C(OCCN4CCOCC4)C=C3)=O)=CC(C(C)(C)C)=N2)C=C1
Molecular Formula
C27H35N5O3
Molecular Weight
477.60
Precautions
H302, H315, H319
References & Citations
[1]Kluter S, et al. Displacement assay for the detection of stabilizers of inactive kinase conformations. J Med Chem. 2010 Jan 14;53 (1) :357-67.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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