MAPK-IN-3

CAT: 0804-HY-169412Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-169412Size:1 Each
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Description
MAPK-IN-3 (Compound 4a) is an anti-proliferative agent that shows particularly strong inhibitory effects on KYSE 30, HCT 116, and HGC 27, with IC50 values of 0.57 μM, 3.27 μM, and 2.28 μM, respectively. MAPK-IN-3 blocks the cell cycle via a p53-dependent mechanism and induces cell apoptosis through a p53-independent mechanism. MAPK-IN-3 downregulates the expression of cell cycle-related proteins like Cyclin D1 and cyclin B1, upregulates pro-apoptotic proteins such as cleaved PARP, cleaved caspase-7, and cleaved caspase-9, and reduces the expression of anti-apoptotic proteins like Bcl-2. Additionally, MAPK-IN-3 increases the intracellular level of ROS in KYSE 30 cells and upregulates the expression of members of the MAPK signaling pathway associated with ROS, such as p-ERK, p-p38 and p-JNK[1].
CAS Number
[2848599-79-9]
UNSPSC
12352005
Target
Bcl-2 Family; Caspase; CDK; ERK; JNK; MDM-2/p53; p38 MAPK; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mapk-in-3.html
Smiles
COC1=C(C=C2OC3=C(C(O)=C(C(OCC(NO)=O)=C3)C/C=C(C)\C)C(C2=C1C/C=C(C)\C)=O)OCC(NO)=O
Molecular Formula
C28H32N2O10
Molecular Weight
556.56
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 7; Caspase 9

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