MAPK-IN-1

• Description :

  MAPK-IN-1 (Compound 2) is a MAPK signaling pathway inhibitor. MAPK-IN-1 exhibits AChE inhibitory activity with an IC50 of 23.84 μM. MAPK-IN-1 shows anti-neuroinflammatory and neuroprotective activity and can be used for Alzheimer's disease research[1].

• UNSPSC :

  12352005

• Target :

  Cholinesterase (ChE) ; ERK; JNK; p38 MAPK; Toll-like Receptor (TLR)

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; Stem Cell/Wnt

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/mapk-in-1.html

• Purity :

  95.85

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1CCC(C2=C(C3=C(C(C2=O)=O)[C@@H](C)CO3)C=C4)=C4C1(C)C

• Molecular Formula :

  C19H18O4

• Molecular Weight :

  310.34

• References & Citations :

  [1]Wu JS, et al. The oxygenated products of cryptotanshinone by biotransformation with Cunninghamella elegans exerting anti-neuroinflammatory effects by inhibiting TLR 4-mediated MAPK signaling pathway. Bioorg Chem. 2020 Nov;104:104246.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  AChE; TLR4

• CAS Number :

  [2470587-69-8]