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MAPK-IN-1

CAT: 0804-HY-146195-01Size: 1 mgDry Ice: NoHazardous: No
CAT#: HY-146195-01Size: 1 mg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MAPK-IN-1 (Compound 2) is a MAPK signaling pathway inhibitor. MAPK-IN-1 exhibits AChE inhibitory activity with an IC50 of 23.84 μM. MAPK-IN-1 shows anti-neuroinflammatory and neuroprotective activity and can be used for Alzheimer's disease research[1].
CAS Number
[2470587-69-8]
UNSPSC
12352005
Target
Cholinesterase (ChE) ; ERK; JNK; p38 MAPK; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mapk-in-1.html
Purity
95.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1CCC(C2=C(C3=C(C(C2=O)=O)[C@@H](C)CO3)C=C4)=C4C1(C)C
Molecular Formula
C19H18O4
Molecular Weight
310.34
References & Citations
[1]Wu JS, et al. The oxygenated products of cryptotanshinone by biotransformation with Cunninghamella elegans exerting anti-neuroinflammatory effects by inhibiting TLR 4-mediated MAPK signaling pathway. Bioorg Chem. 2020 Nov;104:104246.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; TLR4

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