MAPK-IN-1

• Description:

  MAPK-IN-1 (Compound 2) is a MAPK signaling pathway inhibitor. MAPK-IN-1 exhibits AChE inhibitory activity with an IC50 of 23.84 μM. MAPK-IN-1 shows anti-neuroinflammatory and neuroprotective activity and can be used for Alzheimer's disease research[1].

• UNSPSC:

  12352005

• Target:

  Cholinesterase (ChE) ; ERK; JNK; p38 MAPK; Toll-like Receptor (TLR)

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/mapk-in-1.html

• Purity:

  95.85

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1CCC (C2=C (C3=C (C (C2=O) =O) [C@@H] (C) CO3) C=C4) =C4C1 (C) C

• Molecular Formula:

  C19H18O4

• Molecular Weight:

  310.34

• References & Citations:

  [1]Wu JS, et al. The oxygenated products of cryptotanshinone by biotransformation with Cunninghamella elegans exerting anti-neuroinflammatory effects by inhibiting TLR 4-mediated MAPK signaling pathway. Bioorg Chem. 2020 Nov;104:104246.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  AChE; TLR4

• CAS Number:

  2470587-69-8