PROTAC IDO1 Degrader-1

PROTAC IDO1 Degrader-1

• CAS Number: 2488851-89-2
• UNSPSC Description: PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to Cereblon E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells[1].
• Target Antigen: Indoleamine 2,3-Dioxygenase (IDO); PROTACs
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;PROTAC
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/protac-ido1-degrader-1.html
• Purity: 98.17
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C1C2=C(NCCOCCOCCOCCOCCOCCOCCOCCNCCNC3=NON=C3/C(NC4=CC(Br)=C(C=C4)F)=N/O)C=CC=C2C(N1C5C(NC(CC5)=O)=O)=O
• Molecular Weight: 966.80
• References & Citations: [1]Hu M, et al. Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1. Acta Pharm Sin B. 2020;10(10):1943-1953.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported