NecroX-7

• UNSPSC Description:

  NecroX-7 is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing the release of HMGB1 in ischemia/reperfusion injury. NecroX-7 inhibits the HMGB1-induced release of TNF and IL-6, as well as the expression of TLR-4 and receptor for advanced glycation end products. NecroX-7 can be used graft-versus-host disease (GVHD) research[1].

• Target Antigen:

  Interleukin Related; Reactive Oxygen Species; TNF Receptor; Toll-like Receptor (TLR)

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB

• Field of Research:

  Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/necrox-7.html

• Purity:

  99.69

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=S1(CCN(CC1)CC2=CC3=C(C(NC4CCOCC4)=C2)NC(C5=CC=CC=C5)=C3)=O

• Molecular Weight:

  439.57

• References & Citations:

  [1]Im KI, et al. The Free Radical Scavenger NecroX-7 Attenuates Acute Graft-versus-Host Disease via Reciprocal Regulation of Th1/Regulatory T Cells and Inhibition of HMGB1 Release. J Immunol. 2015 Jun 1;194(11):5223-32.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1120332-55-9