NecroX-5

• Description:

  NecroX-5 is a derivative of the NecroX, reduces intracellular calcium concentration, and possesses anti-inflammatory and anti-cancer activity.

• UNSPSC:

  12352005

• Target:

  Calcium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/NecroX-5.html

• Purity:

  98.16

• Solubility:

  DMSO : 170 mg/mL (ultrasonic)

• Smiles:

  O=S1 (CCN (CC2=CC3=C (NC (C4=CC=CC=C4) =C3) C (NCC5CCOCC5) =C2) CC1) =O.CS (=O) (O) =O.CS (=O) (O) =O

• Molecular Formula:

  C27H39N3O9S3

• Molecular Weight:

  645.81

• References & Citations:

  [1]Park JH, et al. NecroX-5 prevents breast cancer metastasis by AKT inhibition via reducing intracellular calcium levels. Int J Oncol. 2017 Jan;50 (1) :185-192.|[2]Thu VT, et al. NecroX-5 exerts anti-inflammatory and anti-fibrotic effects via modulation of the TNFα/Dcn/TGFβ1/Smad2 pathway in hypoxia/reoxygenation-treated rat hearts. Korean J Physiol Pharmacol. 2016 May;20 (3) :305-14.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1383718-29-3