NecroX-5 (free base)

• Description:

  NecroX-5 free base is a derivative of the NecroX, reduces intracellular calcium concentration, and possesses anti-inflammatory and anti-cancer activity.

• UNSPSC:

  12352005

• Target:

  Calcium Channel

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Field of Research:

  Cancer; Inflammation/Immunology

• Smiles:

  O=S1 (CCN (CC1) CC2=CC3=C (C (NCC4CCOCC4) =C2) NC (C5=CC=CC=C5) =C3) =O

• Molecular Formula:

  C25H31N3O3S

• Molecular Weight:

  453.60

• References & Citations:

  [1]Thu VT, et al. NecroX-5 exerts anti-inflammatory and anti-fibrotic effects via modulation of the TNFα/Dcn/TGFβ1/Smad2 pathway in hypoxia/reoxygenation-treated rat hearts. Korean J Physiol Pharmacol. 2016 May;20 (3) :305-14.|[2]Park JH, et al. NecroX-5 prevents breast cancer metastasis by AKT inhibition via reducing intracellular calcium levels. Int J Oncol. 2017 Jan;50 (1) :185-192.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1120332-90-2