BMS-986104

• Description :

  BMS-986104 is a potent and selective S1P1 receptor modulator. BMS-986104 is effective in a mouse EAE model, which is comparable to FTY720. Mechanistically, BMS-986104 exhibites excellent remyelinating effects on lysophosphatidylcholine (LPC) -induced demyelination in a three-dimensional brain cell culture assay.

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  LPL Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Assay Protocol :

  https://www.medchemexpress.com/bms-986104.html

• Smiles :

  OC[C@@]1(C[C@@](CC1)([H])C2=CC=C(C[C@@H](CC3)CCCCCC)C3=C2)N

• Molecular Formula :

  C22H35NO

• Molecular Weight :

  329.52

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

• References & Citations :

  [1]Yang MG, Xiao Z, Dhar TG, et al. Asymmetric Hydroboration Approach to the Scalable Synthesis of ((1R,3S) -1-Amino-3- ((R) -6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl) cyclopentyl) methanol (BMS-986104) as a Potent S1P1 Receptor Modulator. J Med Chem. 2016;59 (24) :11138-11147. |[2]Dhar TG, Xiao HY, Xie J, et al. Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials. ACS Med Chem Lett. 2016;7 (3) :283-288. Published 2016 Jan 19.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [1622180-31-7]