BMS-986104

CAT: 0804-HY-120633Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-120633Size:1 Each
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Description
BMS-986104 is a potent and selective S1P1 receptor modulator. BMS-986104 is effective in a mouse EAE model, which is comparable to FTY720. Mechanistically, BMS-986104 exhibites excellent remyelinating effects on lysophosphatidylcholine (LPC) -induced demyelination in a three-dimensional brain cell culture assay.
CAS Number
[1622180-31-7]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
LPL Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Assay Protocol
https://www.medchemexpress.com/bms-986104.html
Smiles
OC[C@@]1(C[C@@](CC1)([H])C2=CC=C(C[C@@H](CC3)CCCCCC)C3=C2)N
Molecular Formula
C22H35NO
Molecular Weight
329.52
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Yang MG, Xiao Z, Dhar TG, et al. Asymmetric Hydroboration Approach to the Scalable Synthesis of ((1R,3S) -1-Amino-3- ((R) -6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl) cyclopentyl) methanol (BMS-986104) as a Potent S1P1 Receptor Modulator. J Med Chem. 2016;59 (24) :11138-11147. |[2]Dhar TG, Xiao HY, Xie J, et al. Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials. ACS Med Chem Lett. 2016;7 (3) :283-288. Published 2016 Jan 19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

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