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BMS-986224

CAT: 0804-HY-139485-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-139485-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BMS-986224 is a potent, selective and orally active APJ receptor agonist (Kd = 0.3 nM) . BMS-986224 exhibits similar receptor binding and signaling profile to (Pyr1) apelin-13. BMS-986224 has the potential for the research of heart failure[1].
CAS Number
2055200-88-7
UNSPSC
12352005
Target
Apelin Receptor (APJ)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bms-986224.html
Purity
99.44
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1NC(COCC)=C(C2=C(OC)C=CC=C2OC)C(O)=C1C3=NN=C(CC4=NC=C(C=C4)Cl)O3
Molecular Formula
C24H23ClN4O6
Molecular Weight
498.92
References & Citations
[1]Gargalovic P, et al. In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure. Circ Heart Fail. 2021;14 (3) :e007351.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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