UPF-1035

• UNSPSC Description:

  UPF-1035 is a selective PARP-2 inhibitor with an IC50 value of 0.15 μM. UPF-1035 increases CA1 pyramidal cell loss in hippocampal and has neuroprotective activity[1].

• Target Antigen:

  PARP

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/upf-1035.html

• Smiles:

  O=C1C2=CC=CC(OC(C3=CC=CC=C3)=O)=C2C=CN1

• Molecular Weight:

  265.26

• References & Citations:

  [1]F Moroni , et al. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. Br J Pharmacol. 2009 Jul;157(5):854-62.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  370872-09-6