UPF-1035

• Description :

  UPF-1035 is a selective PARP-2 inhibitor with an IC50 value of 0.15 μM. UPF-1035 increases CA1 pyramidal cell loss in hippocampal and has neuroprotective activity[1].

• CAS Number :

  [370872-09-6]

• UNSPSC :

  12352005

• Target :

  PARP

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/upf-1035.html

• Smiles :

  O=C1C2=CC=CC(OC(C3=CC=CC=C3)=O)=C2C=CN1

• Molecular Formula :

  C16H11NO3

• Molecular Weight :

  265.26

• References & Citations :

  [1]F Moroni , et al. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. Br J Pharmacol. 2009 Jul;157 (5) :854-62.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PARP1; PARP2