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UPF-1035

CAT: 0804-HY-14477-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14477-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UPF-1035 is a selective PARP-2 inhibitor with an IC50 value of 0.15 μM. UPF-1035 increases CA1 pyramidal cell loss in hippocampal and has neuroprotective activity[1].
CAS Number
370872-09-6
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/upf-1035.html
Smiles
O=C1C2=CC=CC(OC(C3=CC=CC=C3)=O)=C2C=CN1
Molecular Formula
C16H11NO3
Molecular Weight
265.26
References & Citations
[1]F Moroni , et al. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. Br J Pharmacol. 2009 Jul;157 (5) :854-62.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1; PARP2

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