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UPF-523

CAT: 0804-HY-101311-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101311-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UPF-523 (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a) with an IC50 of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis[1][2].
CAS Number
168560-79-0
Product Name Alternative
AIDA
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/upf-523.html
Purity
99.89
Solubility
DMSO : 9.52 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic; adjust pH to 10 with NaOH)
Smiles
O=C(C1(N)CCC2=C1C=CC(C(O)=O)=C2)O
Molecular Formula
C11H11NO4
Molecular Weight
221.21
References & Citations
[1]Nielsen KS, et al. Class I mGlu receptor antagonist 1-aminoindan-1,5-dicarboxylic acid blocks contextual but not cue conditioning in rats. Eur J Pharmacol. 1997;326 (2-3) :105-108.|[2]Zhang LP, et al. The Role of Type 1 Metabotropic Glutamate Receptors in the Generation of Dorsal Root Reflexes Induced by Acute Arthritis or the Spinal Infusion of 4-Aminopyridine in the Anesthetized Rat. J Pain. 2000;1 (2) :151-161.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 4
Isoform
MGluR1

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