UPF 1069
CAT:
804-HY-14478-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
UPF 1069
- CAS Number: 1048371-03-4
- UNSPSC Description: UPF 1069 is a PARP inhibitor, with IC50s of 8 and 0.3 μM for PARP-1 and PARP-2, respectively.
- Target Antigen: PARP
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Epigenetics
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/UPF-1069.html
- Solubility: DMSO : ≥ 100 mg/mL
- Smiles: O=C1NC=CC2=C1C=CC=C2OCC(C3=CC=CC=C3)=O
- Molecular Weight: 279.29
- References & Citations: [1]Pellicciari R, et al. On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives. ChemMedChem. 2008 Jun;3(6):914-23.|[2]Moroni F, et al. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported