UPF 1069

• Description:

  UPF 1069 is a PARP inhibitor, with IC50s of 8 and 0.3 μM for PARP-1 and PARP-2, respectively.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  PARP

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/UPF-1069.html

• Concentration:

  10mM

• Purity:

  99.02

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C1NC=CC2=C1C=CC=C2OCC(C3=CC=CC=C3)=O

• Molecular Formula:

  C17H13NO3

• Molecular Weight:

  279.29

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Pellicciari R, et al. On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives. ChemMedChem. 2008 Jun;3 (6) :914-23.|[2]Moroni F, et al. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PARP1; PARP2

• CAS Number:

  [1048371-03-4]