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UPF-648

CAT: 0804-HY-15600-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15600-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UPF-648 is a potent kynurenine 3-monooxygenase (KMO) inhibitor; exhibits highly active at 1 uM (81 ± 10% KMO inhibition) ; ineffective at blocking KAT activity.
CAS Number
213400-34-1
UNSPSC
12352005
Target
Aryl Hydrocarbon Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/UPF-648.html
Concentration
10mM
Purity
99.75
Solubility
10 mM in DMSO|Ethanol : ≥ 50 mg/mL
Smiles
O=C([C@@H]1[C@@H](C(C2=CC=C(Cl)C(Cl)=C2)=O)C1)O
Molecular Formula
C11H8Cl2O3
Molecular Weight
259.09
References & Citations
[1]Amori L, et al. On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo. J Neurochem. 2009 Apr;109 (2) :316-25.|[2]Ceresoli-Borroni G, et al. Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications. J Neurosci Res. 2007 Mar;85 (4) :845-54.|[3]Amaral M, et al. Structural basis of kynurenine 3-monooxygenase inhibition. Nature. 2013 Apr 18;496 (7445) :382-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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