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Chemerin-9 (149-157)

CAT: 0804-HY-P1844Size: 1 EachDry Ice: NoHazardous: No
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Description
Chemerin-9 (149-157) is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) has anti-inflammatory activity. Chemerin-9 (149-157) stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) ameliorates Aβ1-42-induced memory impairmen. Chemerin-9 (149-157) regulates immune responses, adipocyte differentiation, and glucose metabolism[1][2][3][4].
CAS Number
676367-27-4
UNSPSC
12352209
Target
Akt; Amyloid-β; Chemerin Receptor; ERK; Reactive Oxygen Species (ROS)
Type
Peptides
Related Pathways
GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/chemerin-9-149-157.html
Solubility
H2O
Smiles
OC[C@@H](C(O)=O)NC([C@H](CC1=CC=CC=C1)NC([C@H](C)NC([C@H](CC2=CC=CC=C2)NC([C@H](CCC(N)=O)NC(CNC([C@H]3N(C([C@H](CC4=CC=CC=C4)NC([C@H](CC5=CC=C(O)C=C5)N)=O)=O)CCC3)=O)=O)=O)=O)=O)=O
Molecular Formula
C54H66N10O13
Molecular Weight
1063.16
References & Citations
[1]Tu J, et, al. Regulatory effect of chemerin and therapeutic efficacy of chemerin 9 in pancreatogenic diabetes mellitus. Mol Med Rep. 2020 Mar;21 (3) :981-988.|[2]Chen S, et, al. Chemerin-9 Attenuates Experimental Abdominal Aortic Aneurysm Formation in ApoE-/- Mice. J Oncol. 2021 Apr 17;2021:6629204.|[3]Lei Z, et, al. Chemerin-9 Peptide Enhances Memory and Ameliorates Aβ1-42-Induced Object Memory Impairment in Mice. Biol Pharm Bull. 2020 Feb 1;43 (2) :272-283.|[4]Yamamoto A, et, al. Chemerin-9 stimulates migration in rat cardiac fibroblasts in vitro. Eur J Pharmacol. 2021 Dec 5;912:174566.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Citation 01
Hypertension. 2024 Apr;81 (4) :861-875.|Eur J Neurosci. 2024 Sep;60 (5) :4830-4842.|Eur J Pharmacol. 2022 Dec 5:936:175343.|MedComm (2020) . 2024 Aug 31;5 (9) :e681.

Chemical Information

chemerin C-terminal peptide
CAS Number676367-27-4
PubChem CID11332190
IUPAC Name(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S)-1-[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoic acid
Molecular FormulaC54H66N10O13
Molecular Weight1063.2
XLogP-1.3
Topological Polar Surface Area371
Hydrogen Bond Donor Count12
Hydrogen Bond Acceptor Count14
Rotatable Bond Count28
Heavy Atom Count77
Formal Charge0
Complexity2000
SMILES
C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CCC(=O)N)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC5=CC=C(C=C5)O)N
InChI
InChI=1S/C54H66N10O13/c1-32(47(69)60-41(28-34-14-7-3-8-15-34)51(73)63-43(31-65)54(76)77)58-50(72)40(27-33-12-5-2-6-13-33)61-49(71)39(23-24-45(56)67)59-46(68)30-57-52(74)44-18-11-25-64(44)53(75)42(29-35-16-9-4-10-17-35)62-48(70)38(55)26-36-19-21-37(66)22-20-36/h2-10,12-17,19-22,32,38-44,65-66H,11,18,23-31,55H2,1H3,(H2,56,67)(H,57,74)(H,58,72)(H,59,68)(H,60,69)(H,61,71)(H,62,70)(H,63,73)(H,76,77)/t32-,38-,39-,40-,41-,42-,43-,44-/m0/s1
InChIKey
QLVGSBXIQFERFK-NBBYSTNSSA-N
Chemical Structure
2D Structure
2D structure of chemerin C-terminal peptide
CAS: 676367-27-4
CID: 11332190
Formula: C54H66N10O13
MW: 1063.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1063.2
XLogP3-1.3
Hydrogen Bond Donor Count12
Hydrogen Bond Acceptor Count14
Rotatable Bond Count28
Exact Mass1062.48108220
Monoisotopic Mass1062.48108220
Topological Polar Surface Area371 Ų
Heavy Atom Count77
Formal Charge0
Complexity2000
Isotope Atom Count0
Defined Atom Stereocenter Count8
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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