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ELB-139

CAT: 0804-HY-106437-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-106437-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ELB-139 is a progesterone analogue. ELB-139 is a GABAA receptor partial agonist. ELB-139 has anxiolytic and anticonvulsant activity. ELB-139 induces increase of extracellular 5-HT in the striatum and the medial prefrontal cortex of rats[1][2].
CAS Number
188116-08-7
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/elb-139.html
Smiles
O=C1N(C2=CC=C(Cl)C=C2)CC(N3CCCCC3)=N1
Molecular Formula
C14H16ClN3O
Molecular Weight
277.75
References & Citations
[1]Rabe H, et al. The novel anxiolytic ELB139 displays selectivity to recombinant GABA (A) receptors different from diazepam. Neuropharmacology. 2007 Mar;52 (3) :796-801.|[2]Langen B, et al. ELB139 an agonist at the benzodiazepine binding site increases 5-HT in the striatum and prefrontal cortex of rats: a microdialysis study. Pharmacol Biochem Behav. 2007 Jan;86 (1) :79-85.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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