PROTAC SMARCA2/4-degrader-7

• UNSPSC Description:

  SMARCA2/4-degrader-7 (compound I-439) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC50s 90 after 24 h of treatment[1].

• Target Antigen:

  PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-smarca2-4-degrader-7.html

• Smiles:

  O=C([C@H]1N(C[C@@H](C1)O)C([C@H](C(C)(C)C)NC([C@@H]2CC[C@@H](C3=CN=C(N4C5CN(C6=C(N)N=NC(C7=C(C=CC=C7)O)=C6)CC4CC5)N=C3)CC2)=O)=O)NC8(C9=CC=C(C%10=C(N=CS%10)C)C=C9)CC8

• Molecular Weight:

  940.17

• References & Citations:

  [1]Preparation of heterocyclic compounds as SMARCA degraders and uses thereof. World Intellectual Property Organization, WO2020251971 A1 2020-12-17.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2568277-89-2