BMS 433796

CAT: 0804-HY-50884-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-50884-01Size:1 mg
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Description
BMS 433796 is a γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's disease.
CAS Number
[935525-13-6]
UNSPSC
12352005
Target
γ-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/BMS_433796.html
Solubility
10 mM in DMSO
Smiles
O[C@@H](C1=CC(F)=CC(F)=C1)C(N[C@@H](C)C(N[C@H]2C3=CC=CC=C3C=NN(C2=O)C)=O)=O
Molecular Formula
C21H20F2N4O4
Molecular Weight
430.40
References & Citations
[1]Prasad CV, et al. Discovery of (S) -2- ((S) -2- (3,5-difluorophenyl) -2-hydroxyacetamido) -N- ((S, Z) -3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl) propanamide (BMS-433796) : a gamma-secretase inhibitor with Abeta lowering activity in a transgenic mouse model of Alzheimer's disease. Bioorg Med Chem Lett. 2007 Jul 15;17 (14) :4006-11.|[2]Goldstein ME, et al. Ex vivo occupancy of gamma-secretase inhibitors correlates with brain beta-amyloid peptide reduction in Tg2576 mice. J Pharmacol Exp Ther. 2007 Oct;323 (1) :102-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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