BMS 433796

• Description:

  BMS 433796 is a γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's disease.

• UNSPSC:

  12352005

• Target:

  γ-secretase

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling; Stem Cell/Wnt

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/BMS_433796.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@@H](C1=CC(F)=CC(F)=C1)C(N[C@@H](C)C(N[C@H]2C3=CC=CC=C3C=NN(C2=O)C)=O)=O

• Molecular Formula:

  C21H20F2N4O4

• Molecular Weight:

  430.40

• References & Citations:

  [1]Prasad CV, et al. Discovery of (S) -2- ((S) -2- (3,5-difluorophenyl) -2-hydroxyacetamido) -N- ((S, Z) -3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl) propanamide (BMS-433796) : a gamma-secretase inhibitor with Abeta lowering activity in a transgenic mouse model of Alzheimer's disease. Bioorg Med Chem Lett. 2007 Jul 15;17 (14) :4006-11.|[2]Goldstein ME, et al. Ex vivo occupancy of gamma-secretase inhibitors correlates with brain beta-amyloid peptide reduction in Tg2576 mice. J Pharmacol Exp Ther. 2007 Oct;323 (1) :102-8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [935525-13-6]