PFI-2

CAT: 0804-HY-18627-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-18627-01Size:5 mg
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Description
PFI-2 ((R) -PFI-2 hydrochloride) hydrochloride, a chemical probe, is a potent and selective SET domain containing lysine methyltransferase 7 (SETD7) inhibitor. (R) -PFI-2 shows high inhibiting activity with IC50 value of 2.0 nM and (S) -PFI-2 shows inhibiting activity with IC50 value of 1.0 μM. PFI-2 hydrochloride can be used for the research of chronic kidney disease and inflammation response in the development of renal fibrosis[1][2].
CAS Number
[1627676-59-8]
Product Name Alternative
(R) -PFI-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/PFI-2.html
Purity
99.68
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=S(C1=CC2=C(CNCC2)C(F)=C1)(N[C@H](CC3=CC=CC(C(F)(F)F)=C3)C(N4CCCC4)=O)=O
Molecular Formula
C23H25F4N3O3S
Molecular Weight
499.52
Precautions
H302, H315, H319, H335
References & Citations
[1]Yuzhen Niu, et al. Revealing inhibition difference between PFI-2 enantiomers against SETD7 by molecular dynamics simulations, binding free energy calculations and unbinding pathway analysis. Sci Rep. 2017 Apr 18;7:46547.|[2]Benquan Liu, et al. Pharmacological inhibition of SETD7 by PFI-2 attenuates renal fibrosis following folic acid and obstruction injury. Eur J Pharmacol. 2021 Jun 15;901:174097.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SETD7/KMT7
Citation 01
Acta Pharmacol Sin. 2022 Feb;43 (2) :457-469.|Biochem Pharmacol. 2024 Jan:219:115964.|Med Oncol. 2023 Apr 12;40 (5) :146.|Patent. US20180263995A1.|Sci Adv. 2023 May 26;9 (21) :eade4186.|Sci Total Environ. 2022 Dec 5;861:160682.|Diabetes. 2025 Jun 1;74 (6) :969-982.|Diabetes. 2025 Oct 1;74 (10) :1825-1838.|Int J Mol Med. 2021 Dec;48 (6) :210.|Mol Carcinog. 2023 Aug;62 (8) :1119-1135.|Proc Natl Acad Sci U S A. 2019 Feb 19;116 (8) :2961-2966. |Research Square Print. September 20th, 2022.

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B1259-5PFI-2
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