PFI-653

CAT: 0804-HY-129035-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-129035-01Size:5 mg
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Description
PFI-653 (Vanin-1-IN-1, compound 3), a chemical probe, is a vanin-1 inhibitor that binds to plasma vanin-1 from mouse, rat, dog, and human. Vanin-1 is a cell surface-associated inositol (GPi) -anchored protein that plays important roles in metabolism and inflammation. PFI-653 inhibits vanin-1 from different species with IC50s of 6.85 nM (human recombinant plasma vanin-1), 9.0 nM (human plasma vanin-1), 24.5 nM (mouse recombinant vanin-1), and 53.4 nM (mouse plasma vanin-1) [1][2].
CAS Number
[2173134-00-2]
Product Name Alternative
Vanin-1-IN-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Pantetheinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pfi-653.html
Purity
99.92
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(N1CC2(CCOCC2)CC1)C3=CN=C(NCC4=NC=CN=C4)N=C3
Molecular Formula
C18H22N6O2
Molecular Weight
354.41
Precautions
H302, H315, H319
References & Citations
[1]Casimiro-Garcia A, et al. Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1. J Med Chem. 2022 Jan 13;65 (1) :757-784.|[2]Agustin Casimiro-Garcia, et al. Novel pyrimidine carboxamides as inhibitors of vanin-1 enzyme. WO2018011681A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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