PFI-90

• Description:

  PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1) .

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H312, H315, H319, H332, H335

• Target:

  Apoptosis; Histone Demethylase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pfi-90.html

• Purity:

  99.86

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=NC=CC=C1)NNC2=NC=CC=C2

• Molecular Formula:

  C11H10N4O

• Molecular Weight:

  214.22

• Precautions:

  H302, H312, H315, H319, H332, H335

• References & Citations:

  [1]KHAN, Javed, et al. Inhibitors of histone demethylases (pfi-63 and pfi-90) for the treatment of cancer and for the inhibition of histone demethylase in cells. WO2021101929A1.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  KDM3

• CAS Number:

  [53995-62-3]