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PFI-7

CAT: 0804-HY-D2259Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-D2259Size:1 Each
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Description
PFI-7 is a probe, which binds to human GID4 (KD is 79 nM), and antagonizes the binding of Pro/N-degrons. PFI-7 can be utilized in C-terminal to LisH (CTLH) complex research and development of targeted protein degradation[1].
CAS Number
2910938-58-6
UNSPSC
12171500
Target
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/pfi-7.html
Smiles
O=C(N[C@@H]1CC[C@H](C2=NC(C=CC=C3)=C3N2)CC1)CNCC4=CC5=C(C=CC=C5)N4
Molecular Formula
C24H27N5O
Molecular Weight
401.50
References & Citations
[1]Owens DDG, et al., A chemical probe to modulate human GID4 Pro/N-degron interactions. Nat Chem Biol. 2024 May 21.
Shipping Conditions
Room temperature
Scientific Category
Dye Reagents
Clinical Information
No Development Reported

Chemical Information

N-[(1s,4s)-4-(1H-benzimidazol-2-yl)cyclohexyl]-N~2~-[(1H-indol-2-yl)methyl]glycinamide
CAS Number2910938-58-6
PubChem CID162396665
IUPAC NameN-[4-(1H-benzimidazol-2-yl)cyclohexyl]-2-(1H-indol-2-ylmethylamino)acetamide
Molecular FormulaC24H27N5O
Molecular Weight401.5
XLogP3.4
Topological Polar Surface Area85.6
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Heavy Atom Count30
Formal Charge0
Complexity578
SMILES
C1CC(CCC1C2=NC3=CC=CC=C3N2)NC(=O)CNCC4=CC5=CC=CC=C5N4
InChI
InChI=1S/C24H27N5O/c30-23(15-25-14-19-13-17-5-1-2-6-20(17)26-19)27-18-11-9-16(10-12-18)24-28-21-7-3-4-8-22(21)29-24/h1-8,13,16,18,25-26H,9-12,14-15H2,(H,27,30)(H,28,29)
InChIKey
HLHNFJNSQZZUNW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-[(1s,4s)-4-(1H-benzimidazol-2-yl)cyclohexyl]-N~2~-[(1H-indol-2-yl)methyl]glycinamide
CAS: 2910938-58-6
CID: 162396665
Formula: C24H27N5O
MW: 401.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight401.5
XLogP33.4
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Exact Mass401.22156050
Monoisotopic Mass401.22156050
Topological Polar Surface Area85.6 Ų
Heavy Atom Count30
Formal Charge0
Complexity578
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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