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FTI-277

CAT: 0804-HY-15872Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-15872Size:1 Each
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Description
FTI-277 is an inhibitor of farnesyl transferase (FTase) ; a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 can inhibit hepatitis delta virus (HDV) infection.
CAS Number
[170006-73-2]
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Apoptosis; Farnesyl Transferase; Ras
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/FTI-277.html
Solubility
10 mM in DMSO
Smiles
CSCC[C@@H](C(OC)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=CC=CC=C2)=O
Molecular Formula
C22H29N3O3S2
Molecular Weight
447.61
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Cohen-Jonathan E, et al. The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS. Radiat Res. 1999 Oct;152 (4) :404-11.|[2]Nakazawa H, et al. Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle. PLoS One. 2015 Jan 16;10 (1) :e0116633.|[3]Virtanen SS, et al. Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells. Cell Biol Int. 2010 Aug;34 (8) :815-26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Fish Shellfish Immunol. 2019 Apr 3;89:281-289.|Oncotarget. 2017 Nov 22;8 (65) :109135-109150. |Adv Sci (Weinh) . 2024 Jun 18:e2307751.|FEBS Open Bio. 2025 Aug 8.|J Cell Mol Med. 2024 Dec;28 (24) :e70273.|Mol Cell Proteomics. 2023 Aug;22 (8) :100593.

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