FTI-277

CAT: 0804-HY-15872Size: 1 EachDry Ice: NoHazardous: No

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Description

FTI-277 is an inhibitor of farnesyl transferase (FTase) ; a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 can inhibit hepatitis delta virus (HDV) infection.

CAS Number

170006-73-2

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Apoptosis; Farnesyl Transferase; Ras

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/FTI-277.html

Solubility

10 mM in DMSO

Smiles

CSCC[C@@H](C(OC)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=CC=CC=C2)=O

Molecular Formula

C22H29N3O3S2

Molecular Weight

447.61

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Cohen-Jonathan E, et al. The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS. Radiat Res. 1999 Oct;152 (4) :404-11.|[2]Nakazawa H, et al. Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle. PLoS One. 2015 Jan 16;10 (1) :e0116633.|[3]Virtanen SS, et al. Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells. Cell Biol Int. 2010 Aug;34 (8) :815-26.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Chemical Information

Fti 277

a ras CAAX (C - Cys; A - aliphatic amino acid; X - Ser or Met) peptidomimetic; inhibits farnesyltransferase; blocks Ras oncogenic signaling by accumulating Ras/Raf complexes in the cytoplasm; structure given in first source

CAS Number	170006-73-2
PubChem CID	3005532
IUPAC Name	methyl (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-phenylbenzoyl]amino]-4-methylsulfanylbutanoate
Molecular Formula	C22H29N3O3S2
Molecular Weight	447.6
XLogP	3.2
Topological Polar Surface Area	120
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	12
Heavy Atom Count	30
Formal Charge	0
Complexity	532

SMILES

COC(=O)[C@H](CCSC)NC(=O)C1=C(C=C(C=C1)NC[C@H](CS)N)C2=CC=CC=C2

InChI

InChI=1S/C22H29N3O3S2/c1-28-22(27)20(10-11-30-2)25-21(26)18-9-8-17(24-13-16(23)14-29)12-19(18)15-6-4-3-5-7-15/h3-9,12,16,20,24,29H,10-11,13-14,23H2,1-2H3,(H,25,26)/t16-,20+/m1/s1

InChIKey

GKFPROVOIQKYTO-UZLBHIALSA-N

Chemical Structure

2D Structure

CAS: 170006-73-2

CID: 3005532

Formula: C22H29N3O3S2

MW: 447.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	447.6
XLogP3	3.2
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	12
Exact Mass	447.16503414
Monoisotopic Mass	447.16503414
Topological Polar Surface Area	120 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	532
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-118916-01	FTI-2148
HY-15873	FTI 276
HY-123242-01	FTI-2153
HY-123242A-01	FTI-2153 (TFA)
HY-15873A-01	FTI 276 (TFA)
HY-118916A	FTI-2148 (diTFA)
HY-130122-01	MG-277
HY-168967	BAY-277
HY-126160	CB10-277
HY-13946-01	BML-277

Alternative Products

Catalog	Name
MBS5802822	FTI 277
GTR19185917-01	FTI-277
MBS3840367-01	FTI-277 HCl
A12368-50	FTI 277 50mg
GTR19188513	FTI 277 TFA
GTR19160439-01	FTI 277 hydrochloride
FHA97734-01	FTI-277 hydrochloride
C12709-1g	FTI 277 HCl
A12368-100	FTI 277 100mg
A12368-25	FTI 277 25mg

FTI-277

Chemical Information

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