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FTI 277 TFA

CAT: 0013-GTR19188513Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19188513Size:25 mg
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Description
FTI 277 TFA is a potent farnesyltransferase (FTase) inhibitor (IC50 = 0.5 nM) that blocks Ras protein processing and MAPK signaling. It exhibits broad antiproliferative activity against various tumor cell lines, including human malignant gliomas, making it a valuable tool for investigating Ras-driven oncogenesis in both cellular and animal models.
CAS Number
1217447-06-7
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction
Smiles
OC (=O) C (F) (F) F.COC (=O) [C@H] (CCSC) NC (=O) c1ccc (NC[C@@H] (N) CS) cc1-c1ccccc1
Molecular Formula
C24H30F3N3O5S2
Molecular Weight
561.64
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

FTI-277 trifluoroacetate salt
CAS Number1217447-06-7
PubChem CID71311821
IUPAC Namemethyl (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-phenylbenzoyl]amino]-4-methylsulfanylbutanoate;2,2,2-trifluoroacetic acid
Molecular FormulaC24H30F3N3O5S2
Molecular Weight561.6
Topological Polar Surface Area157
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count12
Rotatable Bond Count12
Heavy Atom Count37
Formal Charge0
Complexity615
SMILES
COC(=O)[C@H](CCSC)NC(=O)C1=C(C=C(C=C1)NC[C@H](CS)N)C2=CC=CC=C2.C(=O)(C(F)(F)F)O
InChI
InChI=1S/C22H29N3O3S2.C2HF3O2/c1-28-22(27)20(10-11-30-2)25-21(26)18-9-8-17(24-13-16(23)14-29)12-19(18)15-6-4-3-5-7-15;3-2(4,5)1(6)7/h3-9,12,16,20,24,29H,10-11,13-14,23H2,1-2H3,(H,25,26);(H,6,7)/t16-,20+;/m1./s1
InChIKey
GJEFFRDWFVSCOJ-PXPMWPIZSA-N
Chemical Structure
2D Structure
2D structure of FTI-277 trifluoroacetate salt
CAS: 1217447-06-7
CID: 71311821
Formula: C24H30F3N3O5S2
MW: 561.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight561.6
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count12
Rotatable Bond Count12
Exact Mass561.15789790
Monoisotopic Mass561.15789790
Topological Polar Surface Area157 Ų
Heavy Atom Count37
Formal Charge0
Complexity615
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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