BML-277

• Description:

  BML-277 is a selective checkpoint kinase 2 (Chk2) inhibitor with an IC50 of 15 nM.

• Product Name Alternative:

  Chk2 Inhibitor II

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H320, H335

• Target:

  Apoptosis; Checkpoint Kinase (Chk)

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/BML-277.html

• Purity:

  99.74

• Solubility:

  DMSO : 22.22 mg/mL (ultrasonic)

• Smiles:

  ClC(C=C1)=CC=C1OC(C=C2)=CC=C2C3=NC4=CC(C(N)=O)=CC=C4N3

• Molecular Formula:

  C20H14ClN3O2

• Molecular Weight:

  363.80

• Precautions:

  H302, H315, H320, H335

• References & Citations:

  [1]Arienti KL, et al. Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles. J Med Chem. 2005 Mar 24;48 (6) :1873-85.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Chk2

• CAS Number:

  516480-79-8