CB10-277

• Description :

  CB10-277 is a Dacarbazine (HY-B0078) analog that mediates alkylation of guanine residues at the O6 position in DNA and subsequently reduces ATase levels in lymphocytes and tumors. CB10-277 is useful in the study of metastatic malignant melanoma[1].

• CAS Number :

  [7203-91-0]

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H312-H332

• Target :

  DNA Alkylator/Crosslinker; Nucleoside Antimetabolite/Analog

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cb10-277.html

• Smiles :

  O=C(C1=CC=C(C=C1)/N=N/N(C)C)O

• Molecular Formula :

  C9H11N3O2

• Molecular Weight :

  193.20

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

• References & Citations :

  [1]Siow Ming, et al. "In vivo depletion of O 6-alkylguanine-DNA-alkyltransferase in lymphocytes and melanoma of patients treated with CB 10-277, a new DTIC analogue." Cancer chemotherapy and pharmacology 31 (1992) : 240-246.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported