Ripasudil (free base)

• Description:

  Ripasudil free base (K-115 free base) is a specific inhibitor of ROCK, with IC50s of 19 and 51 nM for ROCK2 and ROCK1, respectively.

• Product Name Alternative:

  K-115 (free base)

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  ROCK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/K-115-free-base.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=CN=CC2=C1C(S(N3CCCNC[C@@H]3C)(=O)=O)=CC=C2

• Molecular Formula:

  C15H18FN3O2S

• Molecular Weight:

  323.39

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

• References & Citations:

  [1]Isobe T, et al. Effects of K-115, a rho-kinase inhibitor, on aqueous humor dynamics in rabbits. Curr Eye Res. 2014 Aug;39 (8) :813-22.|[2]Kaneko Y, et al. Effects of K-115 (Ripasudil), a novel ROCK inhibitor, on trabecular meshwork and Schlemm's canal endothelial cells. Sci Rep. 2016 Jan 19;6:19640.|[3]Yamamoto K, et al. The novel Rho kinase (ROCK) inhibitor K-115: a new candidate drug for neuroprotective treatment in glaucoma. Invest Ophthalmol Vis Sci. 2014 Oct 2;55 (11) :7126-36.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  ROCK1; ROCK2

• Citation 01:

  Adv Sci (Weinh) . 2022 May;9 (13) :e2104682.|Curr Eye Res. 2023 Sep;48 (9) :826-835.|Exp Eye Res. 2024 Jun 18:109977.|Mol Ther. 2023 Jun 7;31 (6) :1846-1856.|Preprints. 2023 May 15.|Science. 2017 Dec 1;358 (6367) :eaan4368.

• CAS Number:

  223645-67-8