Ripasudil (free base)

Ripasudil (free base)

• CAS Number: 223645-67-8
• UNSPSC Description: Ripasudil free base (K-115 free base) is a specific inhibitor of ROCK, with IC50s of 19 and 51 nM for ROCK2 and ROCK1, respectively.
• Target Antigen: ROCK
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Cytoskeleton;Stem Cell/Wnt;TGF-beta/Smad
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/K-115-free-base.html
• Solubility: 10 mM in DMSO
• Smiles: FC1=CN=CC2=C1C(S(N3CCCNC[C@@H]3C)(=O)=O)=CC=C2
• Molecular Weight: 323.39
• References & Citations: [1]Isobe T, et al. Effects of K-115, a rho-kinase inhibitor, on aqueous humor dynamics in rabbits. Curr Eye Res. 2014 Aug;39(8):813-22.|[2]Kaneko Y, et al. Effects of K-115 (Ripasudil), a novel ROCK inhibitor, on trabecular meshwork and Schlemm's canal endothelial cells. Sci Rep. 2016 Jan 19;6:19640.|[3]Yamamoto K, et al. The novel Rho kinase (ROCK) inhibitor K-115: a new candidate drug for neuroprotective treatment in glaucoma. Invest Ophthalmol Vis Sci. 2014 Oct 2;55(11):7126-36.Adv Sci (Weinh). 2022 Mar 3;e2104682.|Curr Eye Res. 2023 May 22;1-12.|Exp Eye Res. 2024 Jun 18:109977.|Mol Ther. 2023 Feb 28;S1525-0016(23)00116-8.|Preprints. 2023 May 15.|Science. 2017 Dec 1;358(6367):eaan4368.
• Shipping Conditions: Room temperature
• Clinical Information: Launched