Ripasudil

• UNSPSC Description:

  Ripasudil (K-115) is a specific inhibitor of ROCK, with IC50s of 19 and 51 nM for ROCK2 and ROCK1, respectively.

• Target Antigen:

  ROCK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Cytoskeleton;Stem Cell/Wnt;TGF-beta/Smad

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/K-115.html

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)|H2O : ≥ 50 mg/mL

• Smiles:

  FC1=CN=CC2=C1C(S(N3CCCNC[C@@H]3C)(=O)=O)=CC=C2.[H]Cl.O.O

• Molecular Weight:

  395.88

• References & Citations:

  [1]Isobe T, et al. Effects of K-115, a rho-kinase inhibitor, on aqueous humor dynamics in rabbits. Curr Eye Res. 2014 Aug;39(8):813-22.|[2]Kaneko Y, et al. Effects of K-115 (Ripasudil), a novel ROCK inhibitor, on trabecular meshwork and Schlemm's canal endothelial cells. Sci Rep. 2016 Jan 19;6:19640.|[3]Yamamoto K, et al. The novel Rho kinase (ROCK) inhibitor K-115: a new candidate drug for neuroprotective treatment in glaucoma. Invest Ophthalmol Vis Sci. 2014 Oct 2;55(11):7126-36.Curr Eye Res. 2023 May 22;1-12.|Exp Eye Res. 2024 Jun 18:109977.|Mol Ther. 2023 Feb 28;S1525-0016(23)00116-8.|Preprints. 2023 May 15.|Science. 2017 Dec 1;358(6367):eaan4368.|Adv Sci (Weinh). 2022 Mar 3;e2104682.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  Launched

• CAS Number:

  887375-67-9