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NGD9002 (free base)

CAT: 0804-HY-118935Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-118935Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NGD9002 free base is a new generation of selective corticotropin-releasing factor-1 (CRF-1) receptor antagonist with inhibitory activity on CRF-induced colonic function stimulation. NGD9002 free base can reduce CRF-induced fecal output response and show an inhibitory IC50 value of 4.3 mg/kg. NGD9002 free base can effectively block CRF-induced colonic secretory motility stimulation at the highest dose and reduce acute water avoidance-induced defecation. NGD9002 free base can also prevent the occurrence of pain hypersensitivity reactions to repeated colonic distension[1].
CAS Number
666256-06-0
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ngd9002-free-base.html
Smiles
CC1=C(N=C(C(NC(CC)CC)=N1)OC)C2=CC=C(N=C2NC)C(C)C
Molecular Formula
C20H31N5O
Molecular Weight
357.49
References & Citations
[1]The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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