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JTV-519 (free base)

CAT: 0804-HY-15293ASize: 1 EachDry Ice: NoHazardous: No
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Description
JTV-519 free base (K201 free base) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties[1][2].
CAS Number
145903-06-6
Product Name Alternative
K201 (free base)
UNSPSC
12352005
Hazard Statement
H410
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/jtv-519-free-base.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C2C(CN(C(CCN3CCC(CC4=CC=CC=C4)CC3)=O)CCS2)=C1
Molecular Formula
C25H32N2O2S
Molecular Weight
424.60
Precautions
P273-P391-P501
References & Citations
2+2+
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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