JTV-506

CAT: 0804-HY-19244Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-19244Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JTV-506 is a potent ATP-sensitive potassium channel opener. JTV-506 inhibits Histamine (HY-B1204) -induced contraction of tracheal smooth muscle by activation of KATP channels. JTV-506 attenuates pulmonary vascular tone through its direct action on vascular smooth muscle cells. JTV-506 can be used for pulmonary hypertension research[1][2].
CAS Number
[170148-29-5]
UNSPSC
12352005
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cardiovascular Disease
Smiles
N#CC1=CC=C2C([C@@H](NC(C=C3)=NN(C)C3=O)[C@H](O)C(COC)(COC)O2)=C1
Molecular Formula
C19H22N4O5
Molecular Weight
386.40
References & Citations
[1]Ando T, et al. Effects of JTV-506, a new K+ channel activator, on airway smooth muscle contraction and systemic blood pressure. Clin Exp Allergy. 1997 Jun;27 (6) :705-13.|[2]Tsutsumi Y, et al. JTV-506, a new K (ATP) channel opener, relaxes pulmonary artery isolated from monocrotaline-treated pulmonary hypertensive rats. J Anesth. 2004;18 (3) :210-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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