JTV-506

• Description:

  JTV-506 is a potent ATP-sensitive potassium channel opener. JTV-506 inhibits Histamine (HY-B1204) -induced contraction of tracheal smooth muscle by activation of KATP channels. JTV-506 attenuates pulmonary vascular tone through its direct action on vascular smooth muscle cells. JTV-506 can be used for pulmonary hypertension research[1][2].

• UNSPSC:

  12352005

• Target:

  Potassium Channel

• Related Pathways:

  Membrane Transporter/Ion Channel

• Field of Research:

  Cardiovascular Disease

• Smiles:

  N#CC1=CC=C2C ([C@@H] (NC (C=C3) =NN (C) C3=O) [C@H] (O) C (COC) (COC) O2) =C1

• Molecular Formula:

  C19H22N4O5

• Molecular Weight:

  386.40

• References & Citations:

  [1]Ando T, et al. Effects of JTV-506, a new K+ channel activator, on airway smooth muscle contraction and systemic blood pressure. Clin Exp Allergy. 1997 Jun;27 (6) :705-13.|[2]Tsutsumi Y, et al. JTV-506, a new K (ATP) channel opener, relaxes pulmonary artery isolated from monocrotaline-treated pulmonary hypertensive rats. J Anesth. 2004;18 (3) :210-5.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  170148-29-5