KDOAM-25

• Description :

  KDOAM-25 is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells[1].

• UNSPSC :

  12352005

• Target :

  Histone Demethylase

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/KDOAM-25.html

• Solubility :

  10 mM in DMSO

• Smiles :

  NC(C1=CC=NC(CNCC(N(CC)CCN(C)C)=O)=C1)=O

• Molecular Formula :

  C15H25N5O2

• Molecular Weight :

  307.39

• References & Citations :

  [1]Tumber A, et al. Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. Cell Chem Biol. 2017 Mar 16;24 (3) :371-380.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  KDM5

• Citation 01 :

  Clin Transl Med. 2024 Jun;14 (6) :e1692.|University of Gothenburg. 2023 Jun 27.|bioRxiv. 2024 October 03.|Cancer Sci. 2018 Nov;109 (11) :3602-3610.|Clin Exp Med. 2025 Nov 25;26 (1) :33.|Nat Cell Biol. 2024 Feb;26 (2) :263-277.|Research Square Preprint. 2023 Dec 2.|Sci Adv. 2025 Jun 6;11 (23) :eadu2695.

• CAS Number :

  [2230731-99-2]