KDOAM-25

• UNSPSC Description:

  KDOAM-25 is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells[1].

• Target Antigen:

  Histone Demethylase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/KDOAM-25.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC(C1=CC=NC(CNCC(N(CC)CCN(C)C)=O)=C1)=O

• Molecular Weight:

  307.39

• References & Citations:

  [1]Tumber A, et al. Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. Cell Chem Biol. 2017 Mar 16;24(3):371-380.Clin Transl Med. 2024 Jun;14(6):e1692.|University of Gothenburg. 2023 Jun 27.|bioRxiv. 2024 October 03.|Nat Cell Biol. 2024 Feb;26(2):263-277.|Research Square Preprint. 2023 Dec 2.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2230731-99-2