MK-3328

CAT: 0804-HY-100275Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-100275Size:1 mg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MK-3328 is a β-Amyloid ligand, which exhibits high binding potency with an IC50 of 10.5 nM. MK-3328 is capable of being labelled with 18F for positron emission tomography (PET) imaging[1][2].
CAS Number
[1201323-97-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/MK-3328.html
Purity
99.70
Solubility
10 mM in DMSO
Smiles
CN1C=CC2=CC(C3=NC4=CC=C(F)N=C4O3)=CN=C21
Molecular Formula
C14H9FN4O
Molecular Weight
268.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Harrison ST, et al. Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as β-Amyloid PET Ligands and Identification of MK-3328. ACS Med Chem Lett. 2011 Apr 18;2 (7) :498-502.|[2]Hostetler ED, et al. [18F]Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey. Nucl Med Biol. 2011 Nov;38 (8) :1193-203.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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