OGR-1 Colorimetric Cell-Based ELISA

• Description:

  The OGR-1 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor OGR-1 protein expression profile in cells. The kit can be used for measuring the relative amounts of OGR-1 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on OGR-1.

• Synonyms:

  Ovarian cancer G-protein coupled receptor 1; OGR-1; G-protein coupled receptor 68; GPR12A; Sphingosylphosphorylcholine receptor; GPR68; OGR1

• Gene Name:

  GPR68

• UniProt:

  Q15743

• Reactivity:

  Human, Mouse

• Tissue Specificity:

  Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system.

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca (2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer (By similarity) .

• Molecular Weight:

  41077 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Ovarian cancer G-protein coupled receptor 1

• Subcellular Location:

  Cell membrane; Multi-pass membrane protein.