DOK7 Colorimetric Cell-Based ELISA

• Description:

  The DOK7 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor DOK7 protein expression profile in cells. The kit can be used for measuring the relative amounts of DOK7 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on DOK7.

• Synonyms:

  Protein Dok-7; Downstream of tyrosine kinase 7; DOK7; C4orf25

• Gene Name:

  DOK7

• UniProt:

  Q18PE1

• Reactivity:

  Human, Mouse

• Tissue Specificity:

  Preferentially expressed in skeletal muscle and heart. Present in thigh muscle, diaphragm and heart but not in the liver or spleen (at protein level) .

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK.

• Molecular Weight:

  53097 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Protein Dok-7

• Subcellular Location:

  Cell membrane; Peripheral membrane protein. Cell junction, synapse. Accumulates at neuromuscular junctions.