CLK2 Colorimetric Cell-Based ELISA

CAT: 0519-EKC1731Size: 1 Kit - Containing One 96 Well Plate & All Necessary ReagentsDry Ice: NoHazardous: No
CAT#:0519-EKC1731Size:1 Kit - Containing One 96 Well Plate & All Necessary Reagents
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
The CLK2 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor CLK2 protein expression profile in cells. The kit can be used for measuring the relative amounts of CLK2 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on CLK2.
Synonyms
Dual specificity protein kinase CLK2;2.7.12.1; CDC-like kinase 2; CLK2
Gene Name
CLK2
UniProt
P49760
Reactivity
Human, Mouse, Rat
Tissue Specificity
Endothelial cells.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Molecular Weight
60090 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Dual specificity protein kinase CLK2
Subcellular Location
Isoform 1: Nucleus. Nucleus speckle. Inhibition of phosphorylation at Ser-142 results in accumulation in the nuclear speckle.

Related Products

CatalogName
EKC1627TRIM24 Colorimetric Cell-Based ELISA
EKC1926AFX Colorimetric Cell-Based ELISA
EKC1847QORX Colorimetric Cell-Based ELISA
EKC1624BACH1 Colorimetric Cell-Based ELISA
EKC1793CDK5R2 Colorimetric Cell-Based ELISA
EKC1716ACV1B Colorimetric Cell-Based ELISA
EKC1783MN1 Colorimetric Cell-Based ELISA
EKC1774HSF2 Colorimetric Cell-Based ELISA
EKC1795JIP2 Colorimetric Cell-Based ELISA
EKC1670FES Colorimetric Cell-Based ELISA

Alternative Products

CatalogName
MBS9500762-01CLK2 Colorimetric Cell-Based ELISA Kit
OKAG01252CLK2 Colorimetric Cell-Based ELISA Kit (OKAG01252)
CB5902CLK2 Cell-Based ELISA
MBS9500957-01CBP Colorimetric Cell-Based ELISA Kit
MBS9500933-01PGBD1 Colorimetric Cell-Based ELISA Kit
MBS9500931-01IP3KC Colorimetric Cell-Based ELISA Kit
MBS9500927-01TF3B Colorimetric Cell-Based ELISA Kit
MBS9500925-01FOXJ1 Colorimetric Cell-Based ELISA Kit
MBS9500924-01COPS5 Colorimetric Cell-Based ELISA Kit
MBS9500916-01GRK7 Colorimetric Cell-Based ELISA Kit

Popular Products