SHP-2 Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1522Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No

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CAT#:0519-EKC1522Size:1 Kit, containing one 96 Well Plate and all necessary reagents

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

The SHP-2 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor SHP-2 protein expression profile in cells. The kit can be used for measuring the relative amounts of SHP-2 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on SHP-2.

Synonyms

Tyrosine-protein phosphatase non-receptor type 11;3.1.3.48 ; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3; PTPN11; PTP2C, SHPTP2

Gene Name

PTPN11

UniProt

Q06124

Reactivity

Human, Mouse, Rat

Tissue Specificity

Widely expressed, with highest levels in heart, brain, and skeletal muscle.

Applications

ELISA

Detection Range

> 5000 cells/well

Function

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573) . Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573) . Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426) .

Molecular Weight

68436 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Other Gene Names

Tyrosine-protein phosphatase non-receptor type 11

Subcellular Location

Cytoplasm. Nucleus.

UniProtKB · Q06124

Tyrosine-protein phosphatase non-receptor type 11

PTN11_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q06124
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: PTPN11
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 3.1.3.48
Processing: —
Secondary accessions: A8K1D9, Q96HD7

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Disease

DeafnessDisease variant

Molecular function

HydrolaseProtein phosphatase

Domain

RepeatSH2 domain

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